Clinical Evidence

Evidence for NuvoVi in Clinical Practice

Peer-reviewed data, guideline alignment, and real-world outcomes relevant to pre-bariatric and nutrition-enhancement use.

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RCT Pre-bariatric EN/FR

High-Protein Meal Replacement vs. Standard Diet in Pre-Bariatric Patients

n=124 • 12 weeks • Multicentre

  • Design: Prospective, multicentre clinical program (~12 weeks)
  • Population: 124 pre-bariatric patients (BMI > 35 kg/m²)
  • Intervention: Exercise + high-protein (≥ 1.0 g/kg/day) meal replacement pre-op program

Results

  • Significantly greater pre-op weight loss and readiness for surgery
  • Preserved lean body mass despite calorie restriction
  • No increase in adverse events or dropouts
  • Excellent adherence compared with standard diet counseling
Full Study
RCT Glycemic / Metabolic EN

Protein-Rich, Low-Glycaemic Meal Replacement Strategy

n=119 • 12 weeks • Randomized Controlled Trial (ACOORH subanalysis)

  • Design: 12-week randomized, controlled trial (subanalysis of ACOORH)
  • Population: 119 adults with overweight/obesity and metabolic risk factors
  • Intervention: High-protein (~1.1 g/kg/day), low-GI meal replacement plan vs conventional diet counseling

Results

  • Significant reductions in fasting glucose and lipids; improved dietary quality
  • Higher protein intake and lower fat/carbohydrate intake vs control at 12 weeks
  • Improved satiety / reduced snacking; good tolerability and adherence
Full Study
Meta-analysis Pre-bariatric EN

Pre-operative VLED Prior to Bariatric Surgery

4 RCTs • 588 participants • Systematic Review & Meta-analysis

  • Design: Systematic review & meta-analysis of randomized controlled trials (search through Feb 2023)
  • Population: Adults undergoing elective bariatric surgery
  • Intervention: 2–4 weeks of liquid very-low-energy diet (e.g., Optifast/Modifast) vs non-VLED control

Results

  • Pre-op weight loss: Significantly greater with VLED (MD 3.38 kg; p=0.004)
  • Post-op morbidity: Trend toward reduction at 30 days (RR 0.67; not statistically significant)
  • VLEDs commonly recommended 2–4 weeks pre-op in guidelines; reduce liver volume and perceived operative difficulty
Full Study

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